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CDC20, TOP2A and NEK2 Expression in Esophageal Squamous Cell Carcinoma and Its Clinical Significance

Authors

  • Yanjiao Liu Email Handan City First Hospital, Handan, Hebei, 056000, China
  • Longying He Handan City First Hospital, Handan, Hebei, 056000, China
  • Qian Zhang Handan City First Hospital, Handan, Hebei, 056000, China
  • Xinglong Zhang Handan City First Hospital, Handan, Hebei, 056000, China

DOI:

https://doi.org/10.30564/jor.v2i2.2549
Received: 11 November 2020 | Published Online: 16 December 2020

Abstract

Objective: to study the expression and clinical significance CDC20,TOP2A, NEK2 esophageal squamous cell carcinoma. Methods: Toselect 70 patients with esophageal squamous cell carcinoma, Between August 2018 - August 2020, All intraoperative pathological specimens,A group -35 cases), Cancer tissue, B group, adjacent tissues), two groups of CDC20, TOP2A, NEK 2 expression were detected and analyzed by immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction -RT-PcR) assay.Results: the values of CDC20,TOP2A, NEK2 expression level in A group were significantly higher than
those in B group -P<0.05). The expression level CDC20, TOP2A, NEK2
esophageal squamous cell carcinoma was positively correlated with TNM
stage and lymphatic metastasis, and negatively correlated with tumor
differentiation. Conclusion: CDC20, TOP2A, NEK2 high expression level
directly affects the metastasis, recurrence and prognosis of esophageal
squamous cell carcinoma. The combination of three indexes can accurately
evaluate the pathological status of patients with esophageal squamous cell
carcinoma and help to judge the prognosis of patients accurately

Keywords:

Esophageal squamous cell carcinoma, CDC20, TOP2A, NEK2, Clinical significance

References

[1] Xiangyang Le, Mengni Yun, Qianbin Li, et al. Progress in the cdc20 of new tumor therapeutic targets[J]. Journal of Pharmacy, 2017, 52(9): 1366-1371.

[2] Yanli Guo, Xiaoliang Liang, Gang Kuang, et al. Screening and validation of key hub genes in esophageal squamous cell carcinoma based on bioinformatics analysis[J]. Chinese Journal of Cancer Biotherapy, 2019, 26(2): 166-172.

[3] Dongsheng Niu. Expression of CDC20, TOP2A, NEK2 in esophageal squamous cell carcinoma and its correlation with I clinicopathological features and prognosis. Journal of Applied Cancer, 10(33): 1579-1581.

[4] Guifang Zhang, Lingxin Meng, Zhaojun Ding. Advances in molecular targeted therapy of esophageal cancer[J]. Chinese Journal of Physicians, 2015(z2): 226-229.

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Issue

2020 Vol.2 No.2

Article Type

Article

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Copyright © 2020 Yanjiao Liu, Longying He, Qian Zhang, Xinglong Zhang

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.